Download Acute and Chronic Cough by Anthony E. Redington, Alyn H. Morice PDF

By Anthony E. Redington, Alyn H. Morice

A accomplished evaluate of the clinical and medical points of acute and protracted cough, this reference makes a speciality of contemporary advancements in our figuring out of the molecular biology of putative cough receptors, the neural mechanisms occupied with the afferent and efferent limbs, the crucial processing of the cough reflex, and peptides and different components which may mediate or modulate the cough reflex. With chapters written by means of stated gurus within the box, this guide covers present and strength healing brokers, a number of methodologies to degree cough reflex sensitivity, and medical ways for the overview of power cough in adults and kids.

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Additional resources for Acute and Chronic Cough

Example text

The elderly, newborns, lung transplant patients, and patients with paralysis or neuromuscular disorders have a poorly developed and/or compromised cough reflex and are rendered highly susceptible to lung infections and aspiration pneumonia (1–4). Under normal conditions, therefore, coughing serves an important protective role in the airways and lungs. In diseases such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux disease, and rhinitis, however, cough may become excessive and nonproductive, and is potentially harmful to the airway mucosa (4).

Subtypes of RARs and SARs have also been proposed (13–15,18,35,71,72). Differences in the airway segments innervated and not differences in the physiological properties of the SARs and RARs likely account in part for some of the subtypes described. In other instances, it Afferent Pathways Regulating the Cough Reflex 35 could be argued that the evidence for SAR and RAR subtypes is more an argument of semantics than physiology. For example, Bergren and Peterson (72) and Ho et al. (13) both described a population of myelinated afferent nerves innervating the airways of rats that were activated vigorously by lung deflation yet adapted rapidly to sustained lung inflation.

J Biol Chem 2003; 278:5462–5472. 102. Noguchi K, Morita Y, Kiyama H, Ono K, Tohyama M. A noxious stimulus induces the preprotachykinin—a gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry. Brain Res 1988; 464:31–35. 103. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 1994; 62:327–331. 104. Ji RR, Zhang Q, Law PY, Low HH, Elde R, Hokfelt T.

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