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By Suna F. Kiraç

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6% vs. 15) vs. 1 vs. 7% vs. 31 Table 5. 3 Acute coronary syndromes – ST elevation ACS The cornerstone of management in ST elevation ACS is the timely restoration of flow in the infarct related artery. The accepted strategies for reperfusion include primary PCI and thrombolysis. If available within a timely fashion from an experienced team, urgent coronary angiography and primary PCI offers better patient outcomes than thrombolysis in STEACS. In addition, primary PCI is recommended in patients with cardiogenic shock or contraindication to thrombolysis.

2006). , 2004). , 2004). Furthermore, Kavurma et al. , 2008). Interestingly, they showed the importance of insulin-like growth factor-1 (IGF-1), one of the most potent growth factors, in TRAIL-induced proliferation of VSMCs. , 2008). It is thus too soon to decide whether TRAIL causes apoptosis or proliferation in VSMCs, even in vitro. , 2000). In either case, TRAIL appears to have multiple functions in both physiological and pathological cells under various conditions. As described previously, the existence of five different types of TRAIL receptors and the crosstalk among multiple post-receptor signaling pathways may explain these diverse effects.

2006). Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med, Vol. 12, No. 9, (August 2006) pp. 1075-1080, ISSN 1078-8956 Corallini, F, et al. (2006). TRAIL, caspases and maturation of normal and leukemic myeloid precursors. Leuk Lymphoma, Vol. 47, No. 8, (September 2006) pp. 1459-1468, ISSN 1042-8194 Corallini, F, et al. (2007). Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. J Cell Physiol, Vol.

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