By G. David Perkin
An authoritative creation to Parkinson's affliction and its similar issues and syndromes, this ebook offers a concise evaluation of the ailment and its prognosis and administration. the writer offers samples of medical, investigative (CT, MRI, and puppy) and pathological photographs with succinct descriptive textual content of the problems featured. He describes the stipulations regarding Parkinson's affliction, and the images supply pathological macroscopic and microscopic sections, numerous imaging stories, and info of flow issues more often than not. The e-book will function an invaluable educating device that demonstrates the imaging and pathology of the ailment.
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Extra info for An Illustrated Pocketbook of Parkinson’s Disease and Related Disorders
In such patients, the autonomic failure is due to intermediolateral column degeneration in the spinal cord, whereas the parkinsonian syndrome reflects the classical features of idiopathic Parkinson’s disease, including typical changes in the substantia nigra and locus ceruleus, with Lewy body formation. In other patients described as having multiple system atrophy, the autonomic failure is due to the same pathological process in the spinal cord, but the other clinical features represent a combination, in varying degrees, of striatonigral degeneration and olivopontocerebellar atrophy (OPCA).
Subcortical nuclei are also affected, with the most prominent changes being found in the substantia nigra. Other affected areas include the lateral thalamic nuclei, globus pallidus, subthalamic nuclei, locus ceruleus, and red nucleus. A characteristic, but non-specific, finding is the presence of swollen achromatic neurons (balloon cells) in the affected cortical areas (Figures 43 and 44). These neurons (sometimes called Pick bodies) are tau-positive. A number of inclusion bodies have been found: those with a weakly basophilic body, called the corticobasal inclusion body, and small, more basophilic bodies which may represent a variant of the former rather than a distinct entity (Figure 45).
Various eye movement changes are described, including abnormalities of pursuit and saccades. Intellectual changes affect the ability to plan and carry out sequential processes, coupled with defects of memory and the ability to acquire new information. Behavioral abnormalities include lability, withdrawal, and substantial changes in personality. 50 AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE Figure 52 Spasmodic torticollis: abnormal neck posture Juvenile cases (defined as onset before the age of 20 years) account for approximately 5% of cases and usually inherit the disease from affected fathers.