Download Biliary Lithiasis: Basic Science, Current Diagnosis and by Giuseppe (EDT)/ Cordiano, Claudio (EDT) Borzellino PDF

By Giuseppe (EDT)/ Cordiano, Claudio (EDT) Borzellino

The publication provides an assessment on biliary lithiasis and all its scientific photographs, two decades after the 1st laparoscopic cholecystectomy. The gallbladder, the most bile duct and intra-hepatic stones, of their basic and complex forms are illustrated. Chapters are desirous about simple technology, epidemiology, diagnostic and healing approaches to biliary lithiasis. different diagnostic approaches defined contain  invasive and noninvasive imaging,  and treatments think about scientific therapy, open and minimally invasive surgical procedure, endoscopic and percutaneous techniques, either individually and as mixed procedures.  The book's content material is not restricted to the most in general used therapeutic ways pronounced within the literature, but also addresses new and cutting edge healing suggestions for biliary lithiasis. because of its accomplished method, this quantity might be of curiosity not just for GPs amd experts during this box, but in addition to citizens and different surgeon of alternative disciplines.

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Extra info for Biliary Lithiasis: Basic Science, Current Diagnosis and Management

Example text

Unilamellar vesicles can fuse into larger multilamellar vesicles, which are also termed liposomes or liquid crystals. When cultured under specified conditions, rat hepatocytes form couplets with isolated “bile canaliculi” at interfaces between adjoining cells, thus providing a valuable tool for in vitro investigation of the physiology of hepatic biliary secretion of lipids. Using laser light-scattering techniques, it has been possible to visualize vesicle formation within these bile canaliculi after exposure to bile salts.

Vesicles are unilamellar spherical structures and contain phospholipids and cholesterol and only small quantities of bile salts, if any at all. Vesicles are significantly larger than simple or mixed micelles, with diameters between 40 nm and 100 nm, although they are much smaller than liquid crystals, which have diameters exceeding 500 nm and are composed of multilamellar spherical structures. The presence of large quantities of vesicles in hepatic bile suggests the P. Portincasa et al. hepatocyte as their likely origin.

Liposomes or liquid crystals). These liquid crystals are visible by polarizing light microscopy as lipid circular droplets with typical birefringence in the shape of a Maltese cross. Liquid crystals are inherently unstable and could form solid plate-like cholesterol monohydrate crystals, a process termed cholesterol nucleation. As a result, nucleation of cholesterol monohydrate crystals results in a decrease in the amount of cholesterol contained in vesicles but not of cholesterol in micelles, supporting the concept that vesicles could serve as the primary source of cholesterol for nucleation.

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