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Ballard-Barbash et al. yet definitive, research is expanding rapidly for a number of other rare cancers and suggests associations for obesity and cancers of the ovary and liver and for several types of lymphoid and hematological malignancies. Associations between obesity and lung and head and neck cancers are confounded by tobacco use. An important shift in research has been the effort to examine the combined effect of overweight/obesity, physical inactivity, and poor diet. Studies that have examined these combinations of factors have found much greater increases in risk among people who have these adverse health profiles.

However, incidence and mortality rates of HCC have been increasing rapidly in the United States since the mid-1980s [131]. Hepatitis C and hepatitis B infection and alcoholic liver disease are known risk factors. However, only hepatitis C infection has contributed to the increase in the United States in recent decades, suggesting remaining unidentified risk factors [77–81]. Diabetes and aflatoxins also are known to be risk factors [22]. 2 Overall Statement A limited literature has examined the association of increased risk of HCC with obesity [172].

Jasik CB, Lustig RH (2008). Adolescent obesity and puberty: the “perfect storm”. Ann N Y Acad Sci, 1135:265–279. 67. Key TJ, Allen NE, Verkasalo PK, Banks E (2001). Energy balance and cancer: the role of sex hormones. Proc Nutr Soc, 60(1):81–89. 68. Kipping RR, Jago R, Lawlor DA (2008). Obesity in children. Part 1: Epidemiology, measurement, risk factors, and screening. BMJ, 337:a1824. 69. Kristal AR, Arnold KB, Schenk JM et al. (2008). Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.

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