By Dennis Krikler (auth.), Professor Dr. M. Schlepper, Dr. B. Olsson (eds.)
Asked to arrange a global assembly on Propafenone (Ryt monorm) we needed to query ourselves, no matter if to just accept this provide simply as physicians or in our capability as chairmen of the learn workforce on arrhythmias and intracardiac electrography of the eu Society of Cardiology. Considerung the "pros and contras" and good acutely aware that one could simply be considered as "product promoter" we, however, decide to set up the Symposion in organization with the learn staff. We felt justified to take action for a couple of purposes: Arrhyth mias and their therapy in addition to the instruments to notice the 1st and to regulate the latter are good in the scope of the research crew. a world symposion supplied the chance to have the "state of the artwork" in arrhythmias and antiarrhythmic therapy completely reviewed by means of the world over well known investigators, therefore serving an academic objective. in addition it used to be the goal and target of the assembly to have what's identified a couple of relatively new drug provided in a serious demeanour and to indicate what's now not recognized, yet might be identified. it's in that context the shows of the loose consultation might be judged. To the cautious reader it is going to develop into obvious that a lot which used to be no longer acknowledged, could be learn "between the lines".
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Additional resources for Cardiac Arrhythmias: Diagnosis Prognosis Therapy
The first is in patients in which the premature ventricular ectopy produces no significant hemodynamic embarrassment. The patient may be symptomatic in terms of occasional palpitations or dizziness but does not have syncope or advanced manifestations of hemodynamic compromise. The true measure of antiarrhythmic drug efficacy in such patients is the prevention of sudden cardiac death, since it is believed (as noted earlier) that underlying structural heart disease concomitant with ventricular ectopy places such an individual at high risk of death.
Circulation 64: 977 Kotler M, Tabaygnik B, Mower M, et al. (1973) Prognostic significance of ventricular ectopic beats with respect to sudden death in the late post-infarction period. Circulation 47: 959 Lown B (1979) Sudden cardiac death: The major challenge confronting contemporary cardiology. Am J Cardiol43: 313 May GS, Eberlein KA, Furburg CD (1982) Second degree prevalence after myocardial infarction: a review oflong-termtrials. Prog Cardiovasc Dis 24: 331 Identification of the Patient at High Risk of Sudden Cardiac Death 19 Morganroth J (1981) Long-term ambulatory ECG recording in the determination of efficacy of new antiarrhythmic agents.
This is not surprising as the combined treatment was not chosen by chance or to follow any previously designed protocol, but simply for the practical purpose of controlling the arrhythmia. Patients in the second group were more severely diseased: the difference is not significant when the two groups are considered separately with P, quinidine, or beta-blocker as single therapies, but it becomes significant when they are considered together, and above all when amiodarone is taken into account. The main point of this comparison is to show (a) that in the first group, combined quinidine-beta-blocker therapy, though less effective than P, is no longer statistically different from it, and (b) that the same applies to the second group of more severe arrhythmias when they are treated with combined amiodarone and quinidine.