Download Diagnosis and Management of Endocrine-related Tumors by Robert B. Page, Richard J. Santen (auth.), Richard J. Santen PDF

By Robert B. Page, Richard J. Santen (auth.), Richard J. Santen M.D., Andrea Manni M.D. (eds.)

Patients with numerous tumors current to the health care professional due to medical manifestations of hormones secreted in extra. This phenomenon attracted the investigative curiosity of such pioneers as Harvey Cushing who famous that pituitary tumors could cause acromegaly and Charles Mayo who linked hyper­ pressure with adrenal medullary neoplasms. present int~rest in endocrine-related tumors has intensified due to the explosive improvement of more recent methodol­ ogy for his or her learn. particular measurements of secretory items, hybridization assays to spot items of genomic translation and quantitative review of tissue hormone receptors have supplied technique of characterizing and accurately following sufferers with endocrine-related tumors. remedies dependent upon those advances are swiftly proliferating. the present quantity makes an attempt to synthesize a lot of this contemporary details with the objective of supplying a valid foundation for making scientific decisions relating to prognosis and administration. Tumors of endocrine glandular tissues in most cases confront practising physi­ cians with tricky administration difficulties. numerous particular good points of those tumors necessitate collaboration between a number of forte disciplines with a view to unravel those difficulties and to supply a excessive point of medical care. for instance, endocrine neoplasms secrete lively hormones or hormone precursors which produce scientific manifestations such a lot widespread to endocrinologists. yes thera­ pies akin to radioactive iodine for thyroid melanoma reap the benefits of the hormone­ responsiveness of those tumors to facilitate therapy. those elements require participants educated in endocrinology to enforce complicated diagnostic and thera­ peutic maneuvers.

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Grade 2 - enlarged sella but sellar floor intact. Suprasellar extension may be present in this group and is staged. In stage A, the tumor does not extend to the floor of the infundibular recess of the 3rd ventricle. In stage B, the tumor does extend to the floor of the infundibular recess (the tuber cinereum). In stage C, the infundibular recess is elevated and distorted. Hardy [120] defined these tumors as macroadenomas. The second major subgroup - invasive adenomas - are defined as tumors which have eroded through the floor of the sella turcica with herniation of tumor tissue into the sphenoid sinus.

125. 126. 127. 128. 129. 130. 131. 132. 133. 134. 135. 136. 137. 138. 139. Gross CE, Binet EF, Esquerra IV: Metrizamide cisternography in the evaluation of pituitary adenomas and the empty sella syndrome. 1 Neurosurg 50: 472-476, 1979. Ghoshhajra K: High-resolution metrizamide CT cisternography in sellar and suprasellar abnormalities. 1 Neurosurg 54: 232-239, 1981. Miller IH, Pena AM, Segall HD: Radiological investigation of sellar region masses in children. Radiol134: 81-87, 1980. Hardy 1: Transsphenoidal surgery of hypersecreting pituitary tumors.

Computerized tomography (CT) permits visualization of the sellar contents as well as the osseous anterior, inferior and posterior margins of the sella [114] (Fig. 14A). The diaphragma sella separates the intra sellar pituitary from the subarachnoid space. As the latter is filled with cerebrospinal fluid of low attenuation and as the sella is filled with pituitary tissue of higher attenuation, the superior border of the intrasellar pituitary and the pituitary stalk can be studied by computerized tomography [115].

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