By Stephen B. Dunnett, M. Bentivoglio, A. Bjorklund, T. Hokfelt
Dopamine is an important neurotransmitter of the mind excited about the regulate of circulation, emotion, and cognition; disturbance in dopamine functionality is linked to issues like Parkinson's sickness, schizophrenia and a focus deficit hyperactivity sickness. This quantity of the guide of Chemical Neuroanatomy presents a chain of intensive severe studies of our current figuring out of crucial facets of dopamine's company and disturbed functionality within the animal and human mind.
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Abbreviations in A, B: CLI, central linear nucleus of the raphe; cpd, cerebral peduncle; DGmo, dentate gyrus, molecular layer; dtd, dorsal tegmental decussation; EW, Edinger-Westphal nucleus; IF, interfascicular nucleus; ipf, interpeduncular fossa; IPNc, interpeduncular nucleus, caudal part; IPNi, interpeduncular nucleus, intermediate part; IPNl, interpeduncular nucleus, lateral part; IPNr, interpeduncular nucleus, rostral part; LM, lateral mammillary nucleus; ml, medial lemniscus; mlf, medial longitudinal fasciculus; MM, medial mammillary nucleus; MT, medial terminal nucleus of the accessory optic tract; mtg, mammillotegmental tract; PN, paranigral nucleus; po, polymorphic layer; POL, posterior limitans nucleus of the thalamus; PP, peripeduncular nucleus; RL, rostral linear nucleus of the raphe; RN, red nucleus; rust, rubrospinal tract; scp, superior cerebellar peduncle; sg, granule cell layer; SNc, substantia nigra, compact part; SNl, substantia nigra, lateral part; SNr, substantia nigra, reticular part; VTA, ventral tegmental area; vtd, ventral tegmental decussation.
1984). These antibodies stain preferentially the DA-containing neurons, although DA is present as a precursor also in the other catecholaminergic cells. In addition, anti-DA antibodies have some fixation requirements (DA would diffuse out of the cell unless glutaraldehyde is used as fixative), which renders difficult the combination of DA immunohistochemistry with the immunohistochemical revelation of other antigens or other labeling techniques. 30 Dopamine circuits and receptors Ch. I Growing interest was and still is raised by neurotransmitter transporters, both for the visualization of neurotransmitter-containing cell populations and for the implications of these molecules in synaptic communication.
The A9 and A10 cell groups were named after Dahlstro¨m and Fuxe (1964). CC, crus cerebri; ip, interpeduncular nucleus. Reproduced with permission from Ho¨kfelt et al. (1976). Ch. I M. Bentivoglio and M. Morelli Fig. 8. The plate illustrates the distribution of dopaminergic cells in the mouse, as shown by tyrosine hydroxylase immunoreactivity in coronal sections through the midbrain of the C57BL/6 mouse. Abbreviations: A9c, caudal part of the A9 cell group; A10c, caudal part of the A10 cell group; CLi, central linear nucleus; fr, fasciculus retroflexus; IF, interfascicular nucleus; IPC, caudal interpeduncular nucleus; IPR, rostral interpeduncular nucleus; mfb, medial forebrain bundle; ml, medial lemniscus; PBP, nucleus parabrachialis pigmentosus; PN, nucleus paranigralis; RRF, retrorubral field; SNC, substantia nigra, pars compacta; SNL, substantia nigra, pars lateralis; SNR, substantia nigra, pars reticulata; VTA, ventral tegmental area; 3n, third nerve.