By Davis L. Temple, Jr. (Eds.)
content material: views on antiallergic brokers / H.F. Hodson --
The mechanism of histamine liberate from mast cells with regards to the motion of antiallergic medicines / J.C. Foreman --
Structure-activity relationships in a brand new category of pyrimido[4,5-b]quinoline antiallergy brokers / T.H. Althuis, S.B. Kadin, L.J. Czuba, P.F. Moore, and H.-J. Hess --
the improvement of phenylenedioxamic acids as power antiallergy brokers / Charles M. corridor and H.G. Johnson --
New, orally powerful chromone derivatives for the therapy of bronchial asthma / H. Cairns --
Antiallergic purinones : a profitable program of QSAR / K.R.H. Wooldridge --
Clinically potent 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) / Akira Nohara --
Pyranenamines : a brand new sequence of effective antiallergic compounds / K.M. Snader, L.W. Chakrin, R.D. Cramer, III, Y.M. Gelernt, C.K. Miao, D.H. Shah, B.M. Sutton, J.W. Venslavsky, and C.R. Willis --
the advance of antiallergic pyranenamine sequence : a QSAR good fortune tale / Richard D. Cramer, III, Kenneth M. Snader, Chester R. Willis, Lawrence W. Chakrin, Jean Thomas, and Blaine M. Sutton --
Oxatomide : the prototype of a chemical sequence of compounds inhibiting either the discharge and the consequences of allergic mediators / F. Awouters, C.J.E. Niemegeers, P.A. Janssen, M. Janssen, J. Vandenberk, L. Kennis, M. Van Der Aa, and A. Van Heertum --
Bronchodilators and different pharmacodynamic brokers / Davis L. Temple, Jr. --
Pathophysiologic derangements within the continual obstructive pulmonary ailments and pharmacologic legislation of airway functionality / Sanford Chodosh --
New facets of [beta]-adrenergic bronchodilator medicines / Carl Kaiser --
fresh ideas in theophylline-like bronchodilator medicinal drugs / Richard J. Seidehamel and Davis L. Temple, Jr. --
customers for a prostaglandin bronchodilator / Charles V. Grudzinskas, Jerauld S. Skotnicki, Sow-Mei L. Chen, M. Brawner Floyd, Jr., William A. Hallett, Robert E. Schaub, Gerald J. Siuta, Allan Wissner, Martin J. Weiss, and Franz Dessy.
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G. K. J. Immun. (1975). 114, 514. 69. Nagai, H . , Kelly, K. H. Int. Archs. Allergy appl. Immun. (1978). 56, 307. 70. B. L. Br. J. Pharmac. (1977). 59, 473. 71. S. A. J. Allergy clin. Immun. (1978). 57, 80. 72. Roy, A . C . T. Biochem. Pharmac. (1974). 23, 917. 73. E. G. Life Sciences (1976). 18, 153. 74. K. W. Immunology (1971). 21, 729. 75. Thon, I-L. & Uvnas, B. Acta Physiol. Scand. (1966). 67, 455. 76. C. In Drugs and Transport Processes ed. A. Callingham. (1974). Macmillan: London, p. 222.
8 (300)' XXXIX I 3 Figure 7. a a a Highest dose tested at which the compound was inactive. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1980. 3. ALTHUIS ET AL. 47 Pyrimido[4,5-b]quinoline Antiallergy Agents Small changes in the size of the 7,8-dialkoxy substituents produced marked alterations in activity (Figure 8). The cyclic 7,8-methylenedioxy (XL) and 7,8-ethylenedioxy (XLI) compounds are 70-140 times less potent intravenously than the 7,8-dimethoxy analog (XXXV) and the methylenedioxy derivative is inactive orally.
G. Br. J. Pharmac. (1973). 49, 128. 65. K. L. Int. Archs. Allergy Appl. Immun. (1970). 38, 68. 66. M. F. J. Immun. (1969). 103, 866. 67. G. Unpublished observations. 68. G. K. J. Immun. (1975). 114, 514. 69. Nagai, H . , Kelly, K. H. Int. Archs. Allergy appl. Immun. (1978). 56, 307. 70. B. L. Br. J. Pharmac. (1977). 59, 473. 71. S. A. J. Allergy clin. Immun. (1978). 57, 80. 72. Roy, A . C . T. Biochem. Pharmac. (1974). 23, 917. 73. E. G. Life Sciences (1976). 18, 153. 74. K. W. Immunology (1971).