By Philip A. Schwartzkroin
As a very translational quarter of biomedical research, epilepsy learn spans a rare breadth of topics and comprises almost each device that smooth neuroscience has at its disposal. The Encyclopedia of uncomplicated Epilepsy examine offers an up to the moment, entire reference for all epilepsy researchers. With knowledgeable checklist of authors, the encyclopedia covers the total spectrum of analysis actions from genes and molecules to animal versions and human sufferers. The encyclopedia's digital layout additionally offers unprecedented entry to common updates and additions, whereas the constrained variation print model offers another choice for possessing this content material. The Encyclopedia of simple Epilepsy learn is a vital source for researchers of all degrees and clinicians who examine epilepsy. * the single entire reference for easy learn and present actions in epilepsy.* digital structure presents quickly and straightforward entry to updates and additions, with restricted print model to be had as well.* comprises over eighty five articles, all written via specialists in epilepsy study.
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Additional info for Encyclopedia of Basic Epilepsy Research
1 expression, resulting in prolonged and enhanced burst activity (see Figure 1). 5. Thus, genetically determined, absence-related SWDs are the result of hypersynchronized, rhythmic excitations and inhibitions that result from complex intrinsic, synaptic, and network mechanisms in thalamus and cortex. ’ Pharmacology of CAE The pharmacological target of typical absence drugs, especially ETX, has been a matter of long-standing controversy. In line with the IT dependence of thalamocortical slow oscillations, the mechanism of action of ETX had initially been attributed to a reduction of this current in TC neurons.
Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia 9(3): 249–263. Gloor P and Fariello RG (1988) Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy. Trends in Neurosciences 11: 63–68. Guberman A, Gloor P, and Sherwin AL (1975) Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenylhydantoin. Neurology 25: 758–764. Inoue M, van Luijtelaar EL, Vossen JM, and Coenen AM (1992) Visual evoked potentials during spontaneously occurring spike-wave discharges in rats.
Are there initiation sites in the cortex, or does neocortex just act as a passive by-stander to a rhythm elaborated within the thalamus? Although the evidence obtained in the feline generalized penicillin model indicates that the occurrence of generalized SW discharges require hyperexcitable neocortical networks, a definitive answer to how absence seizures are initiated, and then generalize within the brain, has been provided by studying WAG/Rij rats. 5 mV 1 mV 20 s Figure 4 Spontaneous field potential activity induced by low (a) and high (b) concentrations of 4-aminopyridine in the thalamocortical slice preparation.