Download Fluorescence Diagnosis and Photodynamic Therapy of Skin by PD. Dr. Clemens Fritsch, Univ.-Prof. Dr. Dr. h.c. Thomas PDF

By PD. Dr. Clemens Fritsch, Univ.-Prof. Dr. Dr. h.c. Thomas Ruzicka (auth.)

This e-book is the main updated book on fluorescence diagnostic (FDAP) and photodynamic treatment (PDT) tools utilized in dermatology. either concepts are shortly worldwide brought as criteria for the delineation and the therapy of cutaneous precancerous phases and tumors, which express gradually expanding numbers as a result of e.g. extra widespread sunlight publicity. Summarizing reviews on greater than 5.000 taken care of sufferers, it deals a finished details on each point of pores and skin tumor detection and therapy. the most a part of the publication makes a speciality of the scientific facets giving targeted descriptions on pores and skin tumor detection in addition to photodynamic therapy of chosen illnesses (solar keratoses, basal telephone carcinomas, squamous mobile carcinomas, Bowen's ailment, psoriasis lesions, etc.). The clinically orientated chapters are supplemented by way of useful guidance for PDT and FDAP. The incorporated atlas is constituted of 270 prime quality colour figures permitting day-by-day use as a handbook.

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Additional resources for Fluorescence Diagnosis and Photodynamic Therapy of Skin Diseases: Atlas and Handbook

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This is another hint for the implication of a damaged stratum corneum for enhanced ALA penetration. l FDAP: Kinetics of ALA-induced Porphyrins in Human Cutaneous Tumors, Psoriasis Lesions and Normal Skin Material and Methods Tissue samples used were: basal cell carcinomas (BCC; n = 32), squamous cell carcinomas (SCC; n = 32), psoriatic lesions (PS; n = 32), normal skin (NS; n= 160). Tumor samples were obtained from patients who underwent surgery. Psoriatic tissue samples were taken from punch biopsies that were excised for histopathological examination.

Bees in the facial skin, nodular Bee, nodular see or sclerodermi- form BCC, FDAP has limitations due to high fluorescence levels in the tumor-surrounding skin or due to weak fluorescence in the defined lesion. For this reason, we investigated if other porphyrin prodrugs such as ALA methyl ester might increase the selectivity of induced porphyrins in certain lesions. Thirty six superficial BCC were treated topically by either ALA (medac GmbH, Wedel, Germany; 20% in Neribas® ointment, Schering, Germany), ALA methylester (20%, Metvix®PhotoCure ASA, Olso, Norway) or TPPS 4 (tetraphenylporphine sulphonate) for 2 or 5 hours (Table 6).

Clinical picture (left) and FDAP (4 h ALA) (right) are evaluated concerning the delineation of tumor borders. Welldefined fluorescing area was marked by red lines, ill-defined by black ones. Sharply demarcated fluorescence was expressed as percent of the total marked area f DAP. U~e of the 111 mo Fluoro( flee for SUlgl( II Pldl1l1l11g Computer assisted measurement of the fluorescence pattern. Fluorescence intensity was characterized according to a fluorescence standard (Fig. 30). Values were given semi-quantitatively as 0= no, 1 = weak, 2 = intermediate, and 3 = strong fluorescence.

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