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Additional info for FNA Cytology in the Diagnosis of Lymphoma (Monographs in Clinical Cytology Vol 18)
A majority of the patients have bone marrow involvement but nodal and extranodal manifestations are common. Patients with high blast levels in the mar- 46 T Cell Neoplasms row are classified as leukemic while a dominating mass disease is categorized as lymphoma. Bone marrow failure with anemia and infections is often the presenting symptom but some patients initially have a symptomatic space occupying mediastinal mass. If untreated the disease is highly aggressive and involvement of CNS, lymph nodes, skin and gonads occur.
Alkaline phosphatase, high-power view. 44 T Cell Neoplasms 104 101 100 100 101 102 103 – cyt CD3 PE > 104 104 100 101 102 103 Lambda/CD8 FITC –> 104 100 100 10 101 102 103 CD7-FITC –> 103 CD19 / CD4 TRI –> 103 102 HLA-DR APC –> 10 10 101 10 10 3 2 0 100 104 104 102 104 101 102 103 CD10 PE –> 101 101 102 103 – cd3-FITC > 100 104 100 102 CD2 TRI –> 103 104 103 102 CD5 APC –> 100 10 104 1 cd5 APC –> 101 104 103 102 10 CD19 cv5 –> 1 0 101 102 103 cd3-FITC –> 4 100 Fig. 6. f T cell lymphoma. Flow cytometry immunophenotyping of fine-needle aspirate from a lymph node with an angioimmunoblastic T cell lymphoma.
All patients have a marked lymphocytosis. Response to chemotherapy is poor and survival is short . Cytology (fig. 2) The tumor cell is medium sized and has a moderate amount of weakly grey-blue cytoplasm. The nucleus is round and often has a large nucleolus. Differential diagnoses: Mantle cell lymphoma, splenic marginal zone lymphoma and CLL. Immunocytochemistry: The cells express CD20 and CD79a. CD5 may be present but CD23 is always absent. Genetics: No constant cytogenetic changes have been reported but p53 abnormalities are seen in over 50% of the cases .