By Stephen Waxman
The sphere of neurology is being remodeled, from a therapeutically nihilistic self-discipline with few potent remedies, to a healing strong point which deals new, potent remedies for problems of the mind and spinal wire. This amazing transformation has bridged neuroscience, molecular medication, and scientific research, and represents a big triumph for biomedical learn. This e-book, which includes chapters via greater than 29 across the world famous specialists who've made significant contributions to neurotherapeutics, tells the tales of the way new remedies for disabling issues of the frightened process, akin to stroke, a number of sclerosis, Parkinson's affliction, and migraine, have been constructed, and explores evolving topics and applied sciences that provide desire for much more potent remedies and eventually treatments for at present untreatable problems of the mind and spinal wire. the 1st a part of this publication stories the advance of recent treatments in neurology, from their inception when it comes to simple technological know-how to their advent into the medical international. It additionally explores evolving subject matters and new applied sciences. This e-book could be of curiosity to everybody - clinicians and simple scientists alike - drawn to ailments of the mind and spinal twine, and within the quest for brand new remedies for those problems. * offers the evolution of the sphere of neurology right into a healing self-discipline * Discusses classes realized from prior successes and purposes to ongoing paintings * Explores the way forward for this box
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Extra info for From NEUROSCIENCE To NEUROLOGY: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology
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Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study, Stroke 28:957-960. Lesage AS et al. (1996). Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway, J Pharmacol Exp Ther 279:759-766. Lewington S et al. (2002). Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies, Lancet 360: 1903-1913.
1 Mechanisms of action of ACE inhibitors and angiotensin II receptor subtype 1 blockers. ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker. particular classes of antihypertensive agents (Anderson, 2003; Bath, 2003; Davis and Donnan, 2003). The Heart Outcomes Prevention Evaluation (HOPE) (The Heart Outcomes Prevention Evaluation Study Investigators, 2000) was a double-blind, randomized, placebo-controlled trial of the use of an ACE inhibitor, ramipril, for the prevention of the composite outcome of MI, stroke, and cardiovascular death in high-risk cardiovascular disease patients.