By Carl Hart
High Price is the harrowing and encouraging memoir of neuroscientist Carl Hart, a guy who grew up in a single of Miami’s hardest neighborhoods and, made up our minds to make a distinction as an grownup, tirelessly applies his medical education to assist store actual lives.
Young Carl didn't see the worth of faculty, learning barely enough to maintain him at the basketball crew. at the present time, he's a state of the art neuroscientist—Columbia University’s first tenured African American professor within the sciences—whose landmark, debatable study is redefining our realizing of addiction.
In this provocative and eye-opening memoir, Dr. Carl Hart recollects his trip of self-discovery, how he escaped a lifetime of crime and medication and shunned changing into one of many crack addicts he now experiences. Interweaving previous and current, Hart is going past the hype as he examines the connection among medicines and delight, selection, and motivation, either within the mind and in society. His findings shed new mild on universal principles approximately race, poverty, and medicine, and clarify why present rules are failing.
Read Online or Download High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society PDF
Similar neuroscience books
Experimental philosophy is a brand new circulation that seeks to come back the self-discipline of philosophy to a spotlight on questions about how humans truly imagine and believe. Departing from a long-standing culture, experimental philosophers exit and behavior systematic experiments to arrive a greater knowing of people's traditional intuitions approximately philosophically major questions.
The fellow Who Mistook His spouse for a Hat brings jointly twenty-four of Oliver Sacks’ such a lot attention-grabbing and cherished case experiences. The sufferers in those pages are faced with virtually inconceivably unusual neurological problems; in Sacks’ telling, their tales are a profound testomony to the adaptability of the human mind and the resilience of the human spirit.
A accomplished, multidisciplinary assessment, Neural Plasticity and reminiscence: From Genes to mind Imaging offers an in-depth, up to date research of the examine of the neurobiology of reminiscence. top experts percentage their clinical event within the box, overlaying quite a lot of themes the place molecular, genetic, behavioral, and mind imaging options were used to enquire how mobile and mind circuits can be changed via event.
Encephalitis Lethargica: in the course of and After the Epidemic is similar to a detective novel a couple of significant scientific secret that is still unsolved. in the course of the Nineteen Twenties and Nineteen Thirties a wierd, very polymorphic affected a lot of the realm even though no longer even as far and wide and definitely now not with a similar indicators.
- Case Files: Neuroscience
- Nanotechnology and the Brain
- Desk Reference for Neuroscience
- The Parietal Lobe (Advances in Neurology)
- Gamma-hydroxybutyrate : molecular, functional, and clinical aspects
Extra resources for High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society
Recognition molecules PSA-NCAM, polysialic acid—neuronal cell adhesion molecule NCAM, neuronal cell adhesion molecules (such as H-CAM, G-CAM, VCAM-1) APP, amyloid precursor protein Integrin N-Cadherin Laminin Tenscin Proteoglycans Heparin-binding growth-associated molecule Glial hyaluronate—binding protein Clusterin or chokes them to death. That is, certain molecules (such as NGF) can interact at proapoptotic "grim reaper" receptors to trigger apoptotic neuronal demise. However, if NGF decides to act on a neuroprotective "bodyguard" receptor, the neuron prospers.
The trick is to be able to do this rationally. Table 1 — 2. Co-transmitter pairs Amine/Amino Acid Peptide Dopamine Enkephalin Dopamine Cholecystokinin Norepinephrine Somatostatin Norepinephrine Enkephalin Norepinephrine Neurotensin Epinephrine Enkephalin Serotonin Substance P Serotonin Thyrotropin-releasing hormone Serotonin Enkephalin Acetylcholine Vasoactive intestinal peptide Acetylcholine Enkephalin Acetylcholine Neurotensin Acetylcholine Luteinizing-hormone-releasing hormone Acetylcholine Somatostatin Gamma aminobutyric acid (GABA) Somatostatin Gamma aminobutyric acid (GABA) Motilin Principles of Chemical Neurotransmission 21 Molecular Neurobiology As mentioned earlier, the purpose of chemical neurotransmission is to alter the function of postsynaptic target neurons.
Thus, the concept of co-transmission has arisen. This often involves a monoamine coupled with a neuropeptide. Under some conditions, the monoamine is released alone; under other conditions, both are released, adding to the repertoire of options for chemical neurotransmission by neurons that contain both neurotransmitters. Incredibly, the neuron thus uses a certain "polypharmacy" of its own. The rationale behind the use and action of many drugs, however, grew up in the era of thinking about one neuron using only one neurotransmitter, so that the more selective a drug, perhaps the better it could modify neurotransmission.