Download High Price: A Neuroscientist's Journey of Self-Discovery by Carl Hart PDF

By Carl Hart

High Price is the harrowing and encouraging memoir of neuroscientist Carl Hart, a guy who grew up in a single of Miami’s hardest neighborhoods and, made up our minds to make a distinction as an grownup, tirelessly applies his medical education to assist store actual lives.

Young Carl didn't see the worth of faculty, learning barely enough to maintain him at the basketball crew. at the present time, he's a state of the art neuroscientist—Columbia University’s first tenured African American professor within the sciences—whose landmark, debatable study is redefining our realizing of addiction.

In this provocative and eye-opening memoir, Dr. Carl Hart recollects his trip of self-discovery, how he escaped a lifetime of crime and medication and shunned changing into one of many crack addicts he now experiences. Interweaving previous and current, Hart is going past the hype as he examines the connection among medicines and delight, selection, and motivation, either within the mind and in society. His findings shed new mild on universal principles approximately race, poverty, and medicine, and clarify why present rules are failing.

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Extra resources for High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society

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Recognition molecules PSA-NCAM, polysialic acid—neuronal cell adhesion molecule NCAM, neuronal cell adhesion molecules (such as H-CAM, G-CAM, VCAM-1) APP, amyloid precursor protein Integrin N-Cadherin Laminin Tenscin Proteoglycans Heparin-binding growth-associated molecule Glial hyaluronate—binding protein Clusterin or chokes them to death. That is, certain molecules (such as NGF) can interact at proapoptotic "grim reaper" receptors to trigger apoptotic neuronal demise. However, if NGF decides to act on a neuroprotective "bodyguard" receptor, the neuron prospers.

The trick is to be able to do this rationally. Table 1 — 2. Co-transmitter pairs Amine/Amino Acid Peptide Dopamine Enkephalin Dopamine Cholecystokinin Norepinephrine Somatostatin Norepinephrine Enkephalin Norepinephrine Neurotensin Epinephrine Enkephalin Serotonin Substance P Serotonin Thyrotropin-releasing hormone Serotonin Enkephalin Acetylcholine Vasoactive intestinal peptide Acetylcholine Enkephalin Acetylcholine Neurotensin Acetylcholine Luteinizing-hormone-releasing hormone Acetylcholine Somatostatin Gamma aminobutyric acid (GABA) Somatostatin Gamma aminobutyric acid (GABA) Motilin Principles of Chemical Neurotransmission 21 Molecular Neurobiology As mentioned earlier, the purpose of chemical neurotransmission is to alter the function of postsynaptic target neurons.

Thus, the concept of co-transmission has arisen. This often involves a monoamine coupled with a neuropeptide. Under some conditions, the monoamine is released alone; under other conditions, both are released, adding to the repertoire of options for chemical neurotransmission by neurons that contain both neurotransmitters. Incredibly, the neuron thus uses a certain "polypharmacy" of its own. The rationale behind the use and action of many drugs, however, grew up in the era of thinking about one neuron using only one neurotransmitter, so that the more selective a drug, perhaps the better it could modify neurotransmission.

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