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By Julius J. Menn

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Simul­ taneously, the core enzyme is altered so that it loses its affinity for the old σ of the vegetative cell. In this manner the old gene-set is turned-off and the new gene-set is turned-on. We do not know whether this scheme of positive control of transcription applies to eucaryotic cells. However, Roeder and Rutter (5) have demonstrated two RNA polymerase activities in rat liver nuclei (apparently differing in subunit structure; Rutter, personal communication) and a shifting balance of three distinct RNA polymerase activi­ ties in developing sea urchin embryos.

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