Download Institute of Classical Osteopathy Year Book 1999 by Jocelyn C. P Proby PDF

By Jocelyn C. P Proby

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Currently, more than 100 serotypes have been identified with HRV-A and HRV-B being the most important of them all (Heymann et al. 2005; Peltola et al. 2008; Bochkov et al. 2011; Kennedy et al. 2012). It has been demonstrated that the pathomechanism of symptoms in rhinoviral respiratory tract infections does not result from the cell damage, unlike influenza virus or RSV action (Winther et al. 1990). Rather, rhinovirus disrupts the tight junctions of the epithelial barrier, which facilitates the translocation of pathogens and stimulates the host’s innate and adaptive immune responses (Rezaee et al.

Dis Model Mech 2:12–17 Bukreyev A, Rollin PE, Tate MK, Yang L, Zaki SR, Shieh W-J, Murphy BR, Collins PL, Sanchez A (2007) Successful topical respiratory tract immunization of primates against Ebola virus. J Virol 81:6379–6388 Bwaka MA, Bonnet MJ, Calain P, Colebunders R, De Roo A, Guimard Y, Katwiki KR, Kibadi K, Kipasa MA, Kuvula KJ, Mapanda BB, Massamba M, Mupapa KD, Muyembe-Tamfum JJ, Ndaberey E, Peters CJ, Rollin PE, Van den Enden E (1999) Ebola hemorrhagic fever in Kikwit, Democratic Republic of Congo: clinical observation in 103 patients.

1999). 7 Experimental Vaccines The following types of vaccines were experimentally tested in animals: • vaccine containing a bare DNA strand with the genes encoding the viral proteins NP, GP, and sGP cloned on plasmids (Jahrling et al. 1999); • vaccine made on the basis of various other viruses containing the genes encoding the EBOV protein. Here, vaccine production employed adenoviruses, attenuated equine encephalitis virus, and vaccinia virus (Kudoyarova-Zubavichene et al. 1999). To this end, an interesting approach has recently been reported using recombinants of human parainfluenza virus type 3 expressing the Ebola virus proteins GP alone or in combination with NP, which were inoculated via the intranasal or tracheal route in rhesus monkeys.

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