By R. Eugene Ramsay, James C. Cloyd, Kevin M. Kelly, Ilo E. Leppik, Emilio Perucca
This quantity within the International overview of Neurobiology sequence addresses the epidemiology, pathophysiology, and therapy of epilepsy in aged sufferers. Demographically, the aged include either the fastest-growing phase of the U.S. inhabitants and the grownup age crew with the top prevalence of epilepsy, but there are rather few guides dedicated to this scientific subgroup. The intersection of those advanced processes-epilepsy and advancing age-will have an expanding influence on scientific and neighborhood care. The etiology, analysis, and differential analysis of epilepsy can all be tormented by the conventional getting older method and via the common comorbidities encountered in an aged inhabitants. Chapters during this e-book overview the results of getting older on mind functionality and on drug metabolism and interactions, overlaying the gamut of study from animal versions of getting older and epilepsy to medical trials and results. subject matters additionally contain the hazards of misdiagnosing prestige epilepticus, the exact concerns encountered in recruiting and holding aged medical trial individuals, and using antiepileptic medicines within the aged. In either the medical institution and the study laboratory, a greater realizing of ways epilepsy may possibly range among more youthful and older sufferers may be precious in identifying the absolute best deal with geriatric sufferers with epilepsy.
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Extra resources for Neurobiology of Epilepsy and Aging, Volume 81
Animal Models in Aging Research: Considerations for Experimental Design The Age Factor Genetic Background Choice of Strain Environmental Influences Genomic Manipulations Resources References Animal models have paved the way for the vast majority of advances in biomedical research. Studies on aged animals are essential for understanding the processes inherent in normal aging and the progression of age-related diseases. Animal models are used to identify physiological changes with age, to identify the genetic basis of normal aging and age-associated disease and degeneration, and to test potential therapeutic interventions.
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