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By Allan Siegel

"This is a vintage assessment ebook for the USMLE half I and is an invaluable addition to common clinical libraries. three Stars."-- Doody's overview provider

This one of a kind try out prep consultant permits you to get to understand fabric on neuroscience path tests and the USMLE Step 1; perform with 500 USMLE Step 1-style questions with referenced solutions; evaluate motives for correct and improper solutions; and construct self belief, talents, and knowledge.

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Characteristics of electrical transmission 1. Current generated by an impulse in one neuron spreads to another neuron through a pathway of low resistance. Such a pathway has been identified at gap junctions. 2. Current generated by voltage-gated channels at the presynaptic neuron flows directly into the postsynaptic neuron. 1 ms). 3. Electrical transmission is not very common in the CNS. B. Characteristics of chemical transmission 1. At chemical synapses, the pre- and postsynaptic cells are separated by synaptic clefts, which are fluid-filled gaps (about 20 to 40 nm).

3. Binding of the neurotransmitter to the receptor results in the replacement of guanosine-5′ diphosphate (GDP) by guanosine-5′ triphosphate (GTP) on the α-subunit of the G-protein. , protein kinase A), which then finally phosphorylate the ion channel to open it. Ions flow across the membrane and a postsynaptic response is elicited. 4. Some examples of metabotropic receptors are as follows: a. Cholinergic muscarinic receptors: b. Acetylcholine (ACh) binds with muscarinic receptors, a Gprotein (Go) is activated, phospholipase C is generated, and two second messengers—IP3 and diacylglycerol (DAG)—are produced.

Synthesis (1) Plasma tryptophan enters the brain by an active uptake process and is hydroxylated at the 5 position, by tryptophan hydroxylase, to form 5-hydroxytryptophan. (2) 5-hydroxytryptophan is immediately decarboxylated to form serotonin. Serotonin is then actively taken up and stored in vesicles, where it is ready for release. b. Release and removal (1) Serotonin is removed from the synaptic cleft by reuptake mechanisms. (2) It is also metabolized by MAO. c. Distribution (1) Serotonin-containing neurons are located in the midline or raphe regions of the medulla, pons, and upper brainstem.

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