By Peter R. Mouton
Stereological equipment offer researchers with remarkable quantitative facts from tissue samples and make allowance for well-evidenced learn advances in a large variety of medical fields. offering a concise advent to the method and alertness of stereological learn in neuroscience, Neurostereology provides a fuller figuring out of using those tools in examine and a way for replicating profitable clinical methods. supplying sound footing for destiny research, Neurostereology is a great tool for easy and medical researchers and complicated scholars trying to combine those tools into their research.
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Extra info for Neurostereology: Unbiased Stereology Of Neural Systems
Wald, M. , Coronado, V. G. 2010. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Filley, C. M. 1998. The behavioral neurology of cerebral white matter. Neurology 50: 1535–1540. , Xu, Z. , Chen, J. 2011. Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus. PLoS ONE 6: e24566.
These findings suggests that chronic neuroinflammation alters cell proliferation, but additional studies to elucidate this mechanism and its direct influence on impeding endogenous proliferation need to establish this point. Notwithstanding, these results advance the potential benefits of anti-inflammatory therapies during the chronic stage of TBI. Taken together, these findings suggest that while TBI is generally considered an acute injury, the disease pathology over the long term includes both a chronic cell death perturbation (neuroinflammation) and a diminished endogenous repair mechanism (cell proliferation).
2011). , 2005). , 2008). , 2012). , 2012). , 2008). Of note, only 10% of new cells in the SGZ survive for up to 4 weeks 30000 Est. # of ki67+ cells in the SVZ 400 200 ** 10000 1000 500 0 Sh a m m co n TB tro Ic l on tra TB Ii ps i co nt ro TB l Ic on tra TB Ii ps i co nt ro TB l Ic on tra TB Ii ps i * 1500 0 m Sh a 2000 20000 0 SGZ ki67+ c *** Sham control Sh a Total # of neurons in hippocampal CA3 600 SVZ ki67+ b *** Est. 3 Hippocampal CA3 cell loss and downregulation of cell proliferation. H&E staining revealed a significant cell loss in the hippocampal CA3 region after chronic TBI (a).