By Zofia Zukowska, Giora Z. Feuerstein
The NPY-family of peptides encompasses numerous teams of neurotransmitters and hormones, which exert diversified organic and pathological activities that endure on all significant very important structures. This ebook is a distinct compilation of the latest breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic problems. The identity of a number of receptors for the contributors of the NPY and PYY kin of peptides presents new possibilities for discovery of particular NPY antagonists and agonists that experience monstrous medical strength. the popularity of the function of NPY in stimulation of foodstuff consumption has already led to discovery of powerful and selective NPY receptor Y-5 antagonists, that are in medical improvement for weight problems. NPY Y1 receptor antagonists are detailed for cardiovascular symptoms. examine into the a number of features of NPY and its receptors in neurological and affective problems is usually actively pursued. The chapters during this e-book are written via across the world popular specialists with the target to synthesize prime techniques and knowledge in aid for translational medicine.
The perfect supplement to this quantity is the booklet NPY relatives of Peptides in Immune problems, irritation, Angiogenesis, and Cancer, lately released through a similar editors within the Birkhäuser e-book sequence Progress in irritation Research. either volumes jointly provide a accomplished evaluation of the NPY kinfolk of peptides.
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Additional info for NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics
Eur J Biochem 206: 957–964 Potter EK, Barden JA, McCloskey MJ, Selbie LA, Tseng A, Herzog H, Shine J (1994) A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24–36), with functional specificity for the presynaptic (Y2) receptor. Eur J Pharmacol 267: 253–262 McLean LR, Buck SH, Krstenansky JL (1990) Examination of the role of the amphipathic alphahelix in the interaction of neuropeptide Y and active cyclic analogues with cell membrane receptors and dimyristoylphosphatidylcholine.
Beck-Sickinger Structural properties of Y receptors Several modeling studies of the Y1 receptor and one model of the Y2 receptor revealed a counter-clockwise arrangement of the seven transmembrane helices when viewed from extracellular side [128–131]. Furthermore TM1 and TM4 were most frequently exposed to the lipid bilayer. The helical packing is guaranteed by interactions between residues of different helices. , a direct interaction between Asp86 (TM2) and Asn316 (TM7). Further contacts include a hydrophobic interaction between Tyr47 (TM1) and Leu303 (TM7) such as a hydrophilic interaction between Thr212 (TM5) and Asn282 (TM6) [128, 132].
Eur J Biochem 268: 877–886 Fabry M, Langer M, Rothen-Rutishauser B, Wunderli-Allenspach H, Hocker H, Beck-Sickinger AG (2000) Monitoring of the internalization of neuropeptide Y on neuroblastoma cell line SK-NMC. Eur J Biochem 267: 5631–5637 Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mely Y, Takeda K, Bucher B, Galzi JL (2002) Rapid internalization and recycling of the human neuropeptide Y Y1 receptor. J Biol Chem 277: 6645–6655 Pheng LH, Dumont Y, Fournier A, Chabot JG, Beaudet A, Quirion R (2003) Agonist- and antagonist-induced sequestration/internalization of neuropeptide Y Y(1) receptors in HEK293 cells.