Download Obesity And the Kidney (Contributions to Nephrology) by Gunter Wolf PDF

By Gunter Wolf

We're presently dealing with an alarming weight problems epidemic, with its recognized future health outcomes resembling metabolic syndrome/type 2 diabetes, cardiovascular illnesses, an elevated prevalence of specific sorts of melanoma, musculoskeletal issues and pulmonary ailments. Experimental and medical facts accrued lately now means that weight problems has additionally a huge impression on renal constitution and serve as. because the adipocyte is taken into account a resource of many hormones and cytokines, weight problems has even more direct affects on renal functionality in addition to mediating high blood pressure. it could possibly on its own set off renal disorder corresponding to focal segmental glomerulosclerosis, but in addition, most of the time, lead to development of persistent renal ailments. the current quantity is the 1st entire compilation devoted to this crucial subject, that includes discussions of pathophysiological in addition to medical features written via the leaders during this rising box of study. It brings jointly pathophysiological strategies on how weight problems impacts renal constitution and serve as, experiences the epidemiology of the matter and gives healing feedback. This e-book is usually recommended for internists, nephrologists, hypertensiologists, cardiologists, and urologists treating sufferers with weight problems and renal illnesses. moreover, easy scientists akin to renal physiologists, renal pathologists, pharmacologists, biochemists, and epidemiologists who desire a finished evaluation of the subject also will take advantage of this publication.

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Additional resources for Obesity And the Kidney (Contributions to Nephrology)

Example text

Halme L, Eklund B, Kyllonen L, Salmela K: Is obesity still a risk factor in renal transplantation? Transpl Int 1997;10:284–288. Johnson DW, Isbel NM, Brown AM, Kay TD, Franzen K, Hawley CM, et al: The effect of obesity on renal transplant outcomes. Transplantation 2002;74:675–681. Bennett WM, McEvoy KM, Henell KR, Valente JF, Douzdjian V: Morbid obesity does not preclude successful renal transplantation. Clin Transplant 2004;18:89–93. Holley JL, Shapiro R, Lopatin WB, Tzakis AG, Hakala TR, Starzl TE: Obesity as a risk factor following cadaveric renal transplantation.

Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006;295:1549–1555. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006;295:1549–1555. Srinivas/Meier-Kriesche 38 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004.

Obesity has also been linked to the development of focal and segmental glomerulosclerosis and obesity related glomerulopathy characterized by glomerulomegaly with proteinuria and progressive loss of renal function. In addition obesity has been implicated in the progression of primary renal disease in the general population [14, 15]. Recently, proteinuria and progressive renal insufficiency have been reported in obese patients undergoing nephrectomy for reasons other than kidney donation [16]. Given that in the transplant patient, hyperfiltration is a necessary and given accompaniment of functional adaptation, obesity could potentially be implicated in post-transplant renal dysfunction.

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