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By Doris H. (Ed.) Clouet

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Extra resources for Phencyclidine An Update

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Al. (1983) have reported the isolation of an endogenous factor from preparative scale porcine brain acid extracts that inhibited the binding of 3H-PCP in rat brain membranes. This paper summarizes those previous findings , and extends the data on this endogenous factor which has now been purified to homogeneity and has been given the name alpha-endopsychosin. EXTRACTION AND PURIFICATION OF ALPHA-ENDOPSYCHOSIN Porcine brains (200) were obtained from Gwaltney Co. and homogenized at 4 °C in five volumes of acid solution (Bennett et al.

In man, intoxication with this agent may lead to dissocia1976). tive behavior, agitation, confusion, convulsions, and coma (Spyker et al. 1980). However, the behavioral aberrations induced by 4-AP differ qualitatively from those induced by PCP.

THE EFFECTS OF PCP ANALOGUES ON COMPONENT Sv If the behavioral activity of PCP is related to its block of presynaptic K channels (Albuquerque et al. 1981; Albuquerque et al. 1983; Blaustein and Ickowicz 1983), PCP-like analogues should block these same K channels with a rank order of potency that parallels their relative in vivo psychotomimetic activity. One of the most behaviorally potent PCP-like agents is TCP (1-[1-(2thienyl)-cyclohexyl] piperidine) (Shannon 1983). Figure 4 illustrates the dose-response curves for the block of components S and T by this drug.

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