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By William MacNee, Adam T. Hill, P. Reid, J. Simpson

A single-volume review of the present literature in breathing issues, The yr in respiration drugs 2003 identifies and evaluates the papers released long ago eighteen months that experience most likely replaced perform, or that expect possible destiny advancements. It offers readers with a state-of-the-science precis of contemporary learn findings, and their implications for medical perform. The publication provides a hugely centred evaluate of the present literature, compiled through knowledgeable workforce from major facilities within the box. it's a functional and available source that every one medical professionals treating respiration stipulations will locate necessary of their day-by-day perform.

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Additionally, animal models have demonstrated that reduced levels of IL12 contribute to the development of enhanced AHR |2|. However, it is GENETICS OF ASTHMA 29 not clear why heterozygosity is associated with a reduced functional response but homozygosity is not. This paper by Eerdewegh et al. provides an elegant model for the investigation of genetic traits in complex diseases. In this study, the authors identify ADAM33 as being significantly associated with asthma. The finding that the association was not influenced by serum IgE, a marker of atopy, suggests that ADAM33 is linked to the asthmatic phenotype per se.

Outcome of wheeze in childhood: symptoms and pulmonary function 25 years later. Am J Respir Crit Care Med 1994; 149:106–12. Wasserfallen JB, Schaller MD, Feihl F, Perret CH. Sudden asphyxic asthma: a distinct clinical entity. Am Rev Respir Dis 1990; 142:108–11. Sur S, Crotty TB, Kephart GM, Hyma BA, Colby TV, Reed CE, Hunt LW, Gleich GJ. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosal. Am Rev Respir Dis 1993; 148: 713–19.

The aim of this study was to assess the usefulness of eNO in detecting and predicting loss of control of asthma and to correlate this with sputum eosinophils and AHR to hypertonic saline. INTERPRETATION. 0002). There were significant differences between the loss of control (LOC) and no LOC groups. These values were similar to these obtained using sputum eosinophils and saline PD15 measurements. An absolute value of eNO of ≥15 ppb, or an increase of ≥10 ppb or 60% over baseline, provided a useful threshold for the detection of ongoing airway inflammation and predicts breakthrough symptoms.

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