Unprecedented in its scope and intensity, this publication brings jointly proteomic techniques in analysis and therapy from all scientific fields, together with medical toxicology. the result's a brand new self-discipline in molecular medication that might revolutionize the therapy and prevention of melanoma, stroke and different critical diseases.
Following an summary of medical proteomics, the authors examine the applied sciences on hand, prior to relocating directly to melanoma, cardiopulmonary ailment, diabetes and stroke. a complete part is dedicated to toxicity and the paintings is rounded off with a dialogue of the way forward for scientific proteomics.Content:
Chapter 1 Preanalytical concerns in medical Proteomic reviews (pages 1–12): Roisean E. Ferguson and Rosamonde E. Banks
Chapter 2 Protein Separation via Two?Dimensional Electrophoresis (pages 13–29): Pamela M. Donoghue, Miroslava Stastna and Prof. Dr. Michael J. Dunn
Chapter three Protein Separation: Liquid Chromatography (pages 31–51): Miroslava Stastna and Dr. Jennifer Van Eyk
Chapter four HPLC in Protein Discovery (pages 53–60): Timothy J. Barder
Chapter five IEF research of Peptides for Biomarkers Discovery (pages 61–71): Ali R. Vaezzadeh, Catherine G. Zimmermann?Ivol, Jacques Deshusses, Alexander Scherl and Denis F. Hochstrasser
Chapter 6 Capillary Electrophoretic Separations for medical Proteomics (pages 73–88): Brian M. Balgley, Weijie Wang, Xueping Fang, Don L. DeVoe and Cheng S. Lee
Chapter 7 Quantitative Proteomics utilizing Nano?LC with excessive Accuracy Mass Spectrometry (pages 89–100): Ljiljana Pasa?Tolic, Jon M. Jacobs, Wei?Jun Qian and Richard D. Smith
Chapter eight Antibody Microarrays for Protein and Glycan Detection (pages 101–111): Songming Chen and Brian B. Haab
Chapter nine Biomarker identity: The position of Experimental layout, facts, and knowledge Sharing (pages 113–120): Marc R. Wilkins
Chapter 10 purposes of strong Isotope Tagging established Quantitative Proteomics in melanoma examine (pages 121–143): Ru Chen, Teresa A. Brentnall and Ruedi Aebersold
Chapter eleven Two?Dimensional Liquid Separations, Protein Microarrays, and Mass Spectrometry in accomplished research of Posttranslational adjustments and Biomarker Discovery in Cancers (pages 145–164): Tasneem H. Patwa, Jia Zhao, David E. Misek and David M. Lubman
Chapter 12 improvement and Use of Reversed?Phase Protein Microarrays for medical purposes (pages 165–175): Virginia Espina, Julia Wulfkuhle, Valerie S. Calvert, Kirsten H. Edmiston, Lance A. Liotta and Emanuel F. Petricoin
Chapter thirteen Cyclin?Dependent Kinase Inhibitors and melanoma: Usefulness of Proteomic techniques in review of the Molecular Mechanisms and Efficacy of Novel Therapeutics (pages 177–202): Marian Hajduch, Helena Skalnikova, Petr Halada, David Vydra, Petr Dzubak, Marta Dziechciarkova, Miroslav Strnad, Danuta Radioch, Suresh Jivan Gadher and Hana Kovarova
Chapter 14 Diagnostic Markers for tracking middle Transplant Rejection (pages 203–215): Dr. Ciara A. McManus, Professor Marlene L. Rose and Prof. Dr. Michael J. Dunn
Chapter 15 The research of Microheterogeneity in Human Plasma Proteins: software to Acute Myocardial Infarction (pages 217–229): Randall W. Nelson, city A. Kiernan, Dobrin Nedelkov, Kemmons A. Tubbs and Eric E. Niederkofler
Chapter sixteen Discovery of Biomarkers for Cardiovascular ailments (pages 231–240): Anthony O. Gramolini and Andrew Emili
Chapter 17 improvement of Biomarker improvement Pipeline: look for Myocardial Ischemia Biomarkers (pages 241–261): Qin Fu, Shijun Sheng and Dr. Jennifer E. Van Eyk
Chapter 18 The Albuminome as a device for Biomarker Discovery (pages 263–278): Rebekah L. Gundry and Robert J. Cotter
Chapter 19 program of Metabolomics to Cardiovascular Biomarker and Pathway Discovery (pages 279–293): Gregory D. Lewis and Robert E. Gerszten
Chapter 20 Urinary Biomarkers in Diabetic Nephropathy and different Glomerular ailments (pages 295–322): John M. Arthur and T. Brian Powell
Chapter 21 Pulmonary Proteomics (pages 323–347): Jan Hirsch, Lorraine B. Ware and Michael A. Matthay
Chapter 22 Proteomics offering Insights into significant Psychiatric problems (pages 349–377): Melanie Focking, Kyla Pennington, Jane English, Prof. Dr. Michael Dunn and David Cotter
Chapter 23 Redox Proteomics research of Oxidative transformed mind Proteins in Alzheimer's affliction and delicate Cognitive Impairment: Insights into the development of This Dementing ailment (pages 379–401): Rukhsana Sultana and D. Allan Butterfield
Chapter 24 Toxicoproteomics: Correlating Tissue and Serum Proteomics in Liver damage (pages 403–433): B. Alex Merrick
Chapter 25 Biomarkers for Renal sickness and Uremic pollutants (pages 435–452): Eric Schiffer, Harald Mischak and Raymond C. Vanholder
Chapter 26 HIV and different Viral monitors (pages 453–480): David R. Graham
Chapter 27 program of Fungal Cyclic Peptides and Metabolites (pages 481–509): Jan Nedved, Miroslav Sulc, Alexandr Jegorov, Anastassios Giannakopulos and Vladimir Havlicek
Chapter 28 Microarray methods to Autoantibody Profiling (pages 511–532): John M. Astle and Thomas Kodadek
Chapter 29 id of Tumor Antigen Directed Autoantibodies (pages 533–547): Sandra Faca and Sam Hanash
Chapter 30 Antibody and opposite trap Protein Microarrays for medical Proteomics (pages 549–569): Harvey B. Pollard, Ofer Eidelman, Meera Srivastava, Catherine Joswik, Stephen Rothwell, Gregory P. Mueller, David M. Jacobowitz, William B. Guggino, Jerry Wright, Pamela L. Zeitlin and Cloud P. Paweletz
Chapter 31 Use of Antibody Microarrays within the research of irritation, Autoimmunity, Viral an infection, and melanoma Metastases (pages 571–592): Rodney Lui, Angus Brown, Bosco Wu, Ming?Wei Lin, John Thompson, Filip Braet, Wayne Dyer, JoDee Lattimore, Peter Macdonald, Stephen Adelstein and Cristobal G. dos Remedios
Chapter 32 the longer term: Translation from Discovery to the hospital – Roles of HUPO and in Biomarker Discovery (pages 593–613): Gilbert S. Omenn and Peipei Ping
Chapter 33 specifications of an outstanding Biomarker: Translation into the medical Laboratory (pages 615–631): Mario Plebani, Martina Zaninotto and Monica Maria Mion
Chapter 34 Translation of Protein Biomarkers for medical improvement (pages 633–651): Ian McCaffery, V. Dan Fitzpatrick, Shen Wu Wang, John M. Rossi, Haifeng Bao, Sid V. Suggs, John Ferbas and Scott D. Patterson
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Extra resources for Clinical Proteomics: From Diagnosis to Therapy
Clinical Chemistry, 51, 189–195. , 42 43 44 45 Kornhuber, J. and Wiltfang, J. (2004) Cerebrospinal ﬂuid amyloid b peptide patterns in Alzheimer’s disease patients and nondemented controls depend on sample pretreatment: indication of carrier-mediated epitope masking of amyloid b peptides. Electrophoresis, 25, 2912–2918. Collins, A. , MacDonald, F. , Brown, D. and Viberti, G. C. (1993) Storage temperature and differing methods of sample preparation in the measurement of urinary albumin. Diabetologia, 36, 993–997.
VanHolder Nephrology Section Ghent University Hospital De Pintelaan 185 9000 Gent Belgium Marc R. Wilkins School of Biotechnology and Biomolecular Sciences University of New South Wales, NSW 2052 Sydney Australia David Vydra Palacky University and University Hospital Olomouc Faculty of Medicine and Dentistry Puskinova 6 77520 Olomouc Czech Republic Jerry Wright Department of Physiology, Johns Hopkins University School of Medicine, JHMI, Baltimore, MD 21205 USA Weijie Wang Calibrant Biosystems, 910 Clopper Road, Suite 220N Gaithersburg, MD 20878 USA Bosco Wu Bosch Institute (F13) The University of Sydney Sydney 2006 Australia Shen Wu Wang Amgen, Inc.
2005) Artifactual isoform proﬁle modiﬁcation following treatment of human plasma or serum with protease inhibitor, monitored by 2-dimensional electrophoresis and mass spectrometry. Biotechniques, 39, 239–247. , Stanton, E. and Jackowski, G. (2003) Processing of serum proteins underlies the mass spectral ﬁngerprinting of myocardial infarction. Journal of Proteome Research, 2, 361–372. , Hogdall, E. , Hogdall, C. , Schou, C. and Heegaard, N. H. H. (2005) Sample handling for mass spectrometric proteomic investigations of human sera.